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Interactions médicamenteuses

Amoxicillin-clavulanic acid + Tetracycline

Gravité: Modérée

Amoxicillin-clavulanic acid and Tetracycline: moderate interaction.

Dernière mise à jour

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Résumé

Bacteriostatic tetracyclines may blunt the bactericidal activity of beta-lactams, which depend on actively growing bacteria. Clinical evidence is mostly from older studies in serious infections such as meningitis.

Ce que signifie cette interaction, en termes simples

Amoxicillin-clavulanic acid and Tetracycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Amoxicillin-clavulanic acid belongs to Anti Bacterial; Tetracycline belongs to Anti Bacterial.

Niveau de preuve: Low

Pourquoi elle survient

Tetracycline-induced inhibition of bacterial protein synthesis and growth reduces beta-lactam killing, which requires cell wall synthesis.

Conduite à tenir

Avoid the combination in severe infections where bactericidal activity is essential. Otherwise monitor clinical response.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amoxicillin-clavulanic acid with Tetracycline?

MediHelp rates the interaction as moderate. Amoxicillin-clavulanic acid and Tetracycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bacteriostatic tetracyclines may blunt the bactericidal activity of beta-lactams, which depend on actively growing bacteria. Clinical evidence is mostly from older studies in serious infections such as meningitis.

How serious is the interaction between Amoxicillin-clavulanic acid and Tetracycline?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in severe infections where bactericidal activity is essential. Otherwise monitor clinical response.

What other medicines interact with Amoxicillin-clavulanic acid?

MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Methotrexate, Pexidartinib, Pretomanid. The full list is on the Amoxicillin-clavulanic acid page.

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