Interactions médicamenteuses
Amphetamine polistirex + Safinamide
Gravité: Contre-indiquée
Amphetamine polistirex and Safinamide: contraindicated interaction.
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Résumé
Amphetamines with an MAO inhibitor risk hypertensive crisis and serotonin syndrome. Safinamide labeling contraindicates concomitant use with sympathomimetic stimulants.
Ce que signifie cette interaction, en termes simples
Amphetamine polistirex and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Amphetamine releases monoamines and inhibits their reuptake while MAO-B inhibition lessens their metabolism, causing additive effects.
Conduite à tenir
Do not co-administer; use a non-stimulant treatment when safinamide is needed. Observe a washout interval after stopping either drug.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Safinamide
- Amitriptyline + Safinamide Contre-indiquée
- Amoxapine + Safinamide Contre-indiquée
- Clomipramine + Safinamide Contre-indiquée
- Cyclobenzaprine + Safinamide Contre-indiquée
- Desipramine + Safinamide Contre-indiquée
- Desvenlafaxine + Safinamide Contre-indiquée
Questions fréquentes
Can I take Amphetamine polistirex with Safinamide?
MediHelp rates the interaction as contraindicated. Amphetamine polistirex and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Amphetamines with an MAO inhibitor risk hypertensive crisis and serotonin syndrome. Safinamide labeling contraindicates concomitant use with sympathomimetic stimulants.
How serious is the interaction between Amphetamine polistirex and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use a non-stimulant treatment when safinamide is needed. Observe a washout interval after stopping either drug.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Clomipramine. The full list is on the Safinamide page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
