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Interactions médicamenteuses

Cyclobenzaprine + Safinamide

Gravité: Contre-indiquée

Cyclobenzaprine and Safinamide: contraindicated interaction.

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Résumé

Safinamide inhibits monoamine oxidase and so reduces serotonin breakdown, while cyclobenzaprine is a tricyclic-related muscle relaxant that inhibits serotonin and norepinephrine reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal. Hypertensive reactions are also possible with tricyclic agents.

Ce que signifie cette interaction, en termes simples

Cyclobenzaprine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Cyclobenzaprine belongs to Musculoskeletal; Safinamide belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Additive serotonergic activity: reversible MAO-B inhibition (selectivity is lost at higher doses) plus monoamine reuptake inhibition

Conduite à tenir

Do not combine; allow at least 14 days after stopping the safinamide before starting cyclobenzaprine, and at least 14 days after stopping cyclobenzaprine before starting the safinamide.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cyclobenzaprine with Safinamide?

MediHelp rates the interaction as contraindicated. Cyclobenzaprine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Safinamide inhibits monoamine oxidase and so reduces serotonin breakdown, while cyclobenzaprine is a tricyclic-related muscle relaxant that inhibits serotonin and norepinephrine reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal. Hypertensive reactions are also possible with tricyclic agents.

How serious is the interaction between Cyclobenzaprine and Safinamide?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow at least 14 days after stopping the safinamide before starting cyclobenzaprine, and at least 14 days after stopping cyclobenzaprine before starting the safinamide.

What other medicines interact with Cyclobenzaprine?

MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.

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