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Interactions médicamenteuses

Desipramine + Safinamide

Gravité: Contre-indiquée

Desipramine and Safinamide: contraindicated interaction.

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Résumé

Safinamide inhibits monoamine oxidase and so reduces serotonin breakdown, while desipramine is a tricyclic antidepressant that blocks norepinephrine reuptake and, to a lesser degree, serotonin reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal. Hypertensive reactions are also possible with tricyclic agents.

Ce que signifie cette interaction, en termes simples

Desipramine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Desipramine belongs to Central Nervous System; Safinamide belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Additive serotonergic activity: reversible MAO-B inhibition (selectivity is lost at higher doses) plus monoamine reuptake inhibition

Conduite à tenir

Do not combine; allow at least 14 days after stopping the safinamide before starting desipramine, and at least 14 days after stopping desipramine before starting the safinamide.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Desipramine with Safinamide?

MediHelp rates the interaction as contraindicated. Desipramine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Safinamide inhibits monoamine oxidase and so reduces serotonin breakdown, while desipramine is a tricyclic antidepressant that blocks norepinephrine reuptake and, to a lesser degree, serotonin reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal. Hypertensive reactions are also possible with tricyclic agents.

How serious is the interaction between Desipramine and Safinamide?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow at least 14 days after stopping the safinamide before starting desipramine, and at least 14 days after stopping desipramine before starting the safinamide.

What other medicines interact with Desipramine?

MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.

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