Drug interactions
Amphotericin b + Digoxin
Severity: Major
Amphotericin b and Digoxin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B often causes hypokalemia and hypomagnesemia, which sensitise the myocardium to digoxin. This can precipitate digoxin toxicity with arrhythmias even at normal serum digoxin levels.
What this interaction means in plain words
Amphotericin b and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amphotericin b belongs to Anti Fungals; Digoxin belongs to Cardiovascular.
Why it happens
Electrolyte depletion (potassium, magnesium) from amphotericin B increases digoxin cardiac sensitivity.
What to do
Monitor potassium and magnesium frequently and keep them in the normal range with supplements. Check digoxin levels and ECG, and watch for signs of toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amphotericin b and Digoxin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Amphotericin b with Digoxin?
MediHelp rates the interaction as major. Amphotericin b and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amphotericin B often causes hypokalemia and hypomagnesemia, which sensitise the myocardium to digoxin. This can precipitate digoxin toxicity with arrhythmias even at normal serum digoxin levels.
How serious is the interaction between Amphotericin b and Digoxin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and magnesium frequently and keep them in the normal range with supplements. Check digoxin levels and ECG, and watch for signs of toxicity.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
