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Interactions médicamenteuses

Antithymocyte globulin rabbit + Human papillomavirus vaccine

Gravité: Modérée

Antithymocyte globulin rabbit and Human papillomavirus vaccine: moderate interaction.

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Résumé

Rabbit antithymocyte globulin causes prolonged T-lymphocyte depletion, which can reduce the antibody response to HPV vaccination. Protection from the vaccine may be incomplete.

Ce que signifie cette interaction, en termes simples

Antithymocyte globulin rabbit and Human papillomavirus vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Niveau de preuve: Moderate

Pourquoi elle survient

Profound T-cell depletion impairs the immune response to the inactivated vaccine.

Conduite à tenir

Complete HPV vaccination before starting therapy when possible. Otherwise delay vaccination until immune reconstitution, or consider revaccination or antibody assessment afterwards.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Antithymocyte globulin rabbit with Human papillomavirus vaccine?

MediHelp rates the interaction as moderate. Antithymocyte globulin rabbit and Human papillomavirus vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rabbit antithymocyte globulin causes prolonged T-lymphocyte depletion, which can reduce the antibody response to HPV vaccination. Protection from the vaccine may be incomplete.

How serious is the interaction between Antithymocyte globulin rabbit and Human papillomavirus vaccine?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete HPV vaccination before starting therapy when possible. Otherwise delay vaccination until immune reconstitution, or consider revaccination or antibody assessment afterwards.

What other medicines interact with Human papillomavirus vaccine?

MediHelp also lists interactions of Human papillomavirus vaccine with, for example, Antithymocyte globulin equine, Atidarsagene autotemcel, Belimumab. The full list is on the Human papillomavirus vaccine page.

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