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Interactions médicamenteuses

Atidarsagene autotemcel + Human papillomavirus vaccine

Gravité: Modérée

Atidarsagene autotemcel and Human papillomavirus vaccine: moderate interaction.

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Résumé

Vaccine safety and efficacy during or after atidarsagene autotemcel treatment have not been studied. Myeloablative conditioning eliminates the recipient's immune memory and the immune system rebuilds afterwards, so vaccination in this window is unlikely to be effective.

Ce que signifie cette interaction, en termes simples

Atidarsagene autotemcel and Human papillomavirus vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Atidarsagene autotemcel belongs to Miscellaneous; Human papillomavirus vaccine belongs to Miscellaneous.

Niveau de preuve: Low

Pourquoi elle survient

Myeloablative conditioning and hematopoietic reconstitution impair vaccine responses.

Conduite à tenir

Give vaccines at least 6 weeks before myeloablative conditioning where feasible. Defer vaccination until hematologic recovery, then revaccinate according to guidelines.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Atidarsagene autotemcel with Human papillomavirus vaccine?

MediHelp rates the interaction as moderate. Atidarsagene autotemcel and Human papillomavirus vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vaccine safety and efficacy during or after atidarsagene autotemcel treatment have not been studied. Myeloablative conditioning eliminates the recipient's immune memory and the immune system rebuilds afterwards, so vaccination in this window is unlikely to be effective.

How serious is the interaction between Atidarsagene autotemcel and Human papillomavirus vaccine?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give vaccines at least 6 weeks before myeloablative conditioning where feasible. Defer vaccination until hematologic recovery, then revaccinate according to guidelines.

What other medicines interact with Human papillomavirus vaccine?

MediHelp also lists interactions of Human papillomavirus vaccine with, for example, Antithymocyte globulin equine, Antithymocyte globulin rabbit, Belimumab. The full list is on the Human papillomavirus vaccine page.

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