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Interactions médicamenteuses

Apalutamide + Caspofungin

Gravité: Modérée

Apalutamide and Caspofungin: moderate interaction.

Dernière mise à jour

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Résumé

Apalutamide is an enzyme inducer and may lower caspofungin exposure, though a significant clinical effect is not well established. Caspofungin clearance is slow and not mainly CYP-dependent.

Ce que signifie cette interaction, en termes simples

Apalutamide and Caspofungin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Apalutamide belongs to Endocrine; Caspofungin belongs to Anti Fungals.

Niveau de preuve: Low

Pourquoi elle survient

Possible induction of caspofungin elimination pathways by apalutamide; the mechanism is not firmly established.

Conduite à tenir

Monitor clinical response to antifungal therapy and consider a higher caspofungin maintenance dose, as with other inducers, if response is inadequate.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Apalutamide with Caspofungin?

MediHelp rates the interaction as moderate. Apalutamide and Caspofungin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is an enzyme inducer and may lower caspofungin exposure, though a significant clinical effect is not well established. Caspofungin clearance is slow and not mainly CYP-dependent.

How serious is the interaction between Apalutamide and Caspofungin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to antifungal therapy and consider a higher caspofungin maintenance dose, as with other inducers, if response is inadequate.

What other medicines interact with Caspofungin?

MediHelp also lists interactions of Caspofungin with, for example, Carbamazepine, Cyclosporin, Cyclosporine. The full list is on the Caspofungin page.

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