Drug interactions
Apalutamide + Caspofungin
Severity: Moderate
Apalutamide and Caspofungin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is an enzyme inducer and may lower caspofungin exposure, though a significant clinical effect is not well established. Caspofungin clearance is slow and not mainly CYP-dependent.
What this interaction means in plain words
Apalutamide and Caspofungin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Caspofungin belongs to Anti Fungals.
Why it happens
Possible induction of caspofungin elimination pathways by apalutamide; the mechanism is not firmly established.
What to do
Monitor clinical response to antifungal therapy and consider a higher caspofungin maintenance dose, as with other inducers, if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Apalutamide and Caspofungin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Caspofungin
- Carbamazepine + Caspofungin Moderate
- Caspofungin + Cyclosporin Moderate
- Caspofungin + Cyclosporine Moderate
- Caspofungin + Dexamethasone Moderate
- Caspofungin + Efavirenz Moderate
- Caspofungin + Fosphenytoin Moderate
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Caspofungin?
MediHelp rates the interaction as moderate. Apalutamide and Caspofungin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is an enzyme inducer and may lower caspofungin exposure, though a significant clinical effect is not well established. Caspofungin clearance is slow and not mainly CYP-dependent.
How serious is the interaction between Apalutamide and Caspofungin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to antifungal therapy and consider a higher caspofungin maintenance dose, as with other inducers, if response is inadequate.
What other medicines interact with Caspofungin?
MediHelp also lists interactions of Caspofungin with, for example, Carbamazepine, Cyclosporin, Cyclosporine. The full list is on the Caspofungin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
