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Interactions médicamenteuses

Doravirine + Phenobarbitone

Gravité: Contre-indiquée

Doravirine and Phenobarbitone: contraindicated interaction.

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Résumé

Phenobarbital is expected to lower doravirine exposure considerably, risking virologic failure and resistance. Labeling contraindicates strong CYP3A inducers with doravirine.

Ce que signifie cette interaction, en termes simples

Doravirine and Phenobarbitone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Doravirine belongs to Anti Virals; Phenobarbitone belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Phenobarbital induces CYP3A4, accelerating doravirine metabolism.

Conduite à tenir

Avoid the combination and use an alternative anticonvulsant or antiretroviral regimen. Allow for the long duration of enzyme induction after stopping phenobarbital before starting doravirine.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Doravirine with Phenobarbitone?

MediHelp rates the interaction as contraindicated. Doravirine and Phenobarbitone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenobarbital is expected to lower doravirine exposure considerably, risking virologic failure and resistance. Labeling contraindicates strong CYP3A inducers with doravirine.

How serious is the interaction between Doravirine and Phenobarbitone?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative anticonvulsant or antiretroviral regimen. Allow for the long duration of enzyme induction after stopping phenobarbital before starting doravirine.

What other medicines interact with Doravirine?

MediHelp also lists interactions of Doravirine with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Doravirine page.

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