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Interactions médicamenteuses

Apalutamide + Lonafarnib

Gravité: Contre-indiquée

Apalutamide and Lonafarnib: contraindicated interaction.

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Résumé

Lonafarnib is a sensitive CYP3A4 substrate, and a strong inducer like apalutamide can reduce its levels considerably, compromising efficacy.

Ce que signifie cette interaction, en termes simples

Apalutamide and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Apalutamide belongs to Endocrine; Lonafarnib belongs to Miscellaneous.

Niveau de preuve: Moderate

Pourquoi elle survient

Apalutamide induces CYP3A4, enhancing the metabolic clearance of lonafarnib.

Conduite à tenir

Do not use together; choose a different antiandrogen. If an inducer must be stopped, wait for induction to resolve before restarting full lonafarnib dosing as directed by labeling.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Apalutamide with Lonafarnib?

MediHelp rates the interaction as contraindicated. Apalutamide and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lonafarnib is a sensitive CYP3A4 substrate, and a strong inducer like apalutamide can reduce its levels considerably, compromising efficacy.

How serious is the interaction between Apalutamide and Lonafarnib?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose a different antiandrogen. If an inducer must be stopped, wait for induction to resolve before restarting full lonafarnib dosing as directed by labeling.

What other medicines interact with Apalutamide?

MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.

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