Drug interactions
Apalutamide + Ranolazine
Severity: Contraindicated
Apalutamide and Ranolazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong CYP3A4 inducer and is expected to markedly reduce ranolazine exposure. Antianginal benefit may be lost.
What this interaction means in plain words
Apalutamide and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apalutamide belongs to Endocrine; Ranolazine belongs to Cardiovascular.
Why it happens
Induction of CYP3A4 and P-gp accelerating ranolazine metabolism.
What to do
Avoid concurrent use, as ranolazine labeling contraindicates strong CYP3A inducers. Use another antianginal during apalutamide therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
- Cobicistat + Ranolazine Contraindicated
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Ranolazine?
MediHelp rates the interaction as contraindicated. Apalutamide and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Apalutamide is a strong CYP3A4 inducer and is expected to markedly reduce ranolazine exposure. Antianginal benefit may be lost.
How serious is the interaction between Apalutamide and Ranolazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use, as ranolazine labeling contraindicates strong CYP3A inducers. Use another antianginal during apalutamide therapy.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Butabarbital. The full list is on the Ranolazine page.
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