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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Apalutamide + Ticagrelor

Gravité: Majeure

Apalutamide and Ticagrelor: major interaction.

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Résumé

Apalutamide is a strong CYP3A4 inducer and substantially lowers ticagrelor and its active metabolite exposure. This could reduce platelet inhibition and risk stent thrombosis or other ischemic events.

Ce que signifie cette interaction, en termes simples

Apalutamide and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Apalutamide belongs to Endocrine; Ticagrelor belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Induction of CYP3A4 (and P-gp) increases ticagrelor clearance.

Conduite à tenir

Avoid the combination and use an alternative antiplatelet or antiandrogen. If unavoidable, monitor for loss of antiplatelet efficacy.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Apalutamide with Ticagrelor?

MediHelp rates the interaction as major. Apalutamide and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide is a strong CYP3A4 inducer and substantially lowers ticagrelor and its active metabolite exposure. This could reduce platelet inhibition and risk stent thrombosis or other ischemic events.

How serious is the interaction between Apalutamide and Ticagrelor?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative antiplatelet or antiandrogen. If unavoidable, monitor for loss of antiplatelet efficacy.

What other medicines interact with Ticagrelor?

MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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