Interactions médicamenteuses
Apixaban + Edoxaban
Gravité: Contre-indiquée
Apixaban and Edoxaban: contraindicated interaction.
Dernière mise à jour
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Résumé
Both are direct factor Xa inhibitors, so using them together duplicates anticoagulation and markedly increases bleeding risk with no added benefit. Overlap is acceptable only briefly when switching between agents.
Ce que signifie cette interaction, en termes simples
Apixaban and Edoxaban are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apixaban belongs to Cardiovascular; Edoxaban belongs to Cardiovascular.
Pourquoi elle survient
Duplicate pharmacodynamic effect through factor Xa inhibition.
Conduite à tenir
Do not co-prescribe. When switching, stop one agent and start the other at the time the next dose of the first would be due.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Apixaban
- Apixaban + Dabigatran Contre-indiquée
- Apixaban + Defibrotide Contre-indiquée
- Apixaban + Ketorolac Contre-indiquée
- Apixaban + Mifepristone Contre-indiquée
- Abciximab + Apixaban Majeure
- Acalabrutinib + Apixaban Majeure
Autres interactions de Edoxaban
- Defibrotide + Edoxaban Contre-indiquée
- Edoxaban + Ketorolac Contre-indiquée
- Abciximab + Edoxaban Majeure
- Acetylsalicylic acid + Edoxaban Majeure
- Argatroban + Edoxaban Majeure
- Aspirin rectal + Edoxaban Majeure
Questions fréquentes
Can I take Apixaban with Edoxaban?
MediHelp rates the interaction as contraindicated. Apixaban and Edoxaban are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are direct factor Xa inhibitors, so using them together duplicates anticoagulation and markedly increases bleeding risk with no added benefit. Overlap is acceptable only briefly when switching between agents.
How serious is the interaction between Apixaban and Edoxaban?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-prescribe. When switching, stop one agent and start the other at the time the next dose of the first would be due.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Ketorolac. The full list is on the Apixaban page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
