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Interactions médicamenteuses

Apixaban + Defibrotide

Gravité: Contre-indiquée

Apixaban and Defibrotide: contraindicated interaction.

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Résumé

Defibrotide has antithrombotic and profibrinolytic effects, so adding apixaban increases the risk of serious bleeding. Defibrotide labeling contraindicates concurrent systemic anticoagulants.

Ce que signifie cette interaction, en termes simples

Apixaban and Defibrotide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Apixaban belongs to Cardiovascular; Defibrotide belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive pharmacodynamic effects on hemostasis from factor Xa inhibition plus enhanced fibrinolysis.

Conduite à tenir

Do not co-administer; interrupt apixaban during defibrotide therapy under specialist guidance. Central line maintenance is the usual exception.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Apixaban with Defibrotide?

MediHelp rates the interaction as contraindicated. Apixaban and Defibrotide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Defibrotide has antithrombotic and profibrinolytic effects, so adding apixaban increases the risk of serious bleeding. Defibrotide labeling contraindicates concurrent systemic anticoagulants.

How serious is the interaction between Apixaban and Defibrotide?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; interrupt apixaban during defibrotide therapy under specialist guidance. Central line maintenance is the usual exception.

What other medicines interact with Apixaban?

MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Edoxaban, Ketorolac. The full list is on the Apixaban page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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