Interactions médicamenteuses
Atidarsagene autotemcel + Nevirapine
Gravité: Majeure
Atidarsagene autotemcel and Nevirapine: major interaction.
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Résumé
Antiretrovirals may interfere with manufacture of the gene-modified cell product by impairing transduction of the harvested cells. Nevirapine therefore needs to be stopped before mobilization and apheresis.
Ce que signifie cette interaction, en termes simples
Atidarsagene autotemcel and Nevirapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atidarsagene autotemcel belongs to Miscellaneous; Nevirapine belongs to Anti Virals.
Pourquoi elle survient
Antiretroviral activity may inhibit lentiviral vector transduction during manufacturing of the cell product.
Conduite à tenir
Discontinue nevirapine at least one month before mobilization, or longer to allow elimination, and until apheresis is complete. Plan an alternative HIV approach with the treating team.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contre-indiquée
- Nevirapine + Ranolazine Contre-indiquée
- Nevirapine + St john's wort Contre-indiquée
- Abemaciclib + Nevirapine Majeure
- Acalabrutinib + Nevirapine Majeure
- Amobarbital + Nevirapine Majeure
Autres interactions de Atidarsagene autotemcel
Questions fréquentes
Can I take Atidarsagene autotemcel with Nevirapine?
MediHelp rates the interaction as major. Atidarsagene autotemcel and Nevirapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antiretrovirals may interfere with manufacture of the gene-modified cell product by impairing transduction of the harvested cells. Nevirapine therefore needs to be stopped before mobilization and apheresis.
How serious is the interaction between Atidarsagene autotemcel and Nevirapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Discontinue nevirapine at least one month before mobilization, or longer to allow elimination, and until apheresis is complete. Plan an alternative HIV approach with the treating team.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
