Interactions médicamenteuses
Azacitidine + Fingolimod
Gravité: Majeure
Azacitidine and Fingolimod: major interaction.
Dernière mise à jour
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Résumé
Azacitidine causes myelosuppression and fingolimod lowers circulating lymphocytes by sequestering them in lymphoid tissue. Together they may increase the risk of serious infection.
Ce que signifie cette interaction, en termes simples
Azacitidine and Fingolimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azacitidine belongs to Oncology; Fingolimod belongs to Central Nervous System.
Pourquoi elle survient
Additive immunosuppression: lymphocyte sequestration from fingolimod plus bone marrow suppression from azacitidine.
Conduite à tenir
Avoid the combination where possible, or monitor blood counts and infection signs closely. Consider stopping fingolimod during cytotoxic therapy, remembering its immune effects persist for weeks after discontinuation.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contre-indiquée
- Bcg vaccine live + Fingolimod Contre-indiquée
- Fingolimod + Pimozide Contre-indiquée
- Fingolimod + Ponesimod Contre-indiquée
- Fingolimod + Quinidine Contre-indiquée
- Fingolimod + Siponimod Contre-indiquée
Autres interactions de Azacitidine
- Azacitidine + Siponimod Majeure
- Azacitidine + Denosumab Modérée
- Azacitidine + Dichlorphenamide Modérée
- Azacitidine + Hydroxyurea Modérée
- Azacitidine + Trastuzumab Modérée
Questions fréquentes
Can I take Azacitidine with Fingolimod?
MediHelp rates the interaction as major. Azacitidine and Fingolimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Azacitidine causes myelosuppression and fingolimod lowers circulating lymphocytes by sequestering them in lymphoid tissue. Together they may increase the risk of serious infection.
How serious is the interaction between Azacitidine and Fingolimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or monitor blood counts and infection signs closely. Consider stopping fingolimod during cytotoxic therapy, remembering its immune effects persist for weeks after discontinuation.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
