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Interactions médicamenteuses

Azacitidine + Trastuzumab

Gravité: Modérée

Azacitidine and Trastuzumab: moderate interaction.

Dernière mise à jour

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Résumé

Azacitidine is myelosuppressive, and trastuzumab has been associated with higher rates of neutropenia and febrile neutropenia when combined with myelosuppressive chemotherapy. The combination may increase infection risk.

Ce que signifie cette interaction, en termes simples

Azacitidine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Azacitidine belongs to Oncology; Trastuzumab belongs to Oncology.

Niveau de preuve: Low

Pourquoi elle survient

Additive hematologic toxicity; trastuzumab may worsen chemotherapy-induced neutropenia by an incompletely understood mechanism.

Conduite à tenir

Monitor complete blood counts regularly and watch for fever or infection; manage neutropenia per standard protocols.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Azacitidine with Trastuzumab?

MediHelp rates the interaction as moderate. Azacitidine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azacitidine is myelosuppressive, and trastuzumab has been associated with higher rates of neutropenia and febrile neutropenia when combined with myelosuppressive chemotherapy. The combination may increase infection risk.

How serious is the interaction between Azacitidine and Trastuzumab?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and watch for fever or infection; manage neutropenia per standard protocols.

What other medicines interact with Trastuzumab?

MediHelp also lists interactions of Trastuzumab with, for example, Daunorubicin, Doxorubicin liposomal, Doxorubicin. The full list is on the Trastuzumab page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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