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Interactions médicamenteuses

Azathioprine + Olaparib

Gravité: Majeure

Azathioprine and Olaparib: major interaction.

Dernière mise à jour

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Résumé

Both drugs suppress bone marrow function, and combining them may deepen or prolong anemia, neutropenia and thrombocytopenia. This raises the risk of infection and bleeding.

Ce que signifie cette interaction, en termes simples

Azathioprine and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Azathioprine belongs to Gastrointestinal Tract; Olaparib belongs to Oncology.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive myelosuppression, with azathioprine impairing purine synthesis and olaparib inhibiting PARP and causing DNA damage in hematopoietic cells.

Conduite à tenir

Monitor complete blood counts frequently, especially in the first months of combined therapy. Reduce the dose of one or both drugs or interrupt therapy if cytopenias develop.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Azathioprine with Olaparib?

MediHelp rates the interaction as major. Azathioprine and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs suppress bone marrow function, and combining them may deepen or prolong anemia, neutropenia and thrombocytopenia. This raises the risk of infection and bleeding.

How serious is the interaction between Azathioprine and Olaparib?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently, especially in the first months of combined therapy. Reduce the dose of one or both drugs or interrupt therapy if cytopenias develop.

What other medicines interact with Azathioprine?

MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.

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