Interactions médicamenteuses
Azilsartan-chlorthalidone + Ethacrynic acid
Gravité: Majeure
Azilsartan-chlorthalidone and Ethacrynic acid: major interaction.
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Résumé
Ethacrynic acid is a potent loop diuretic and combining it with a thiazide-like diuretic produces sequential nephron blockade. This can cause profound diuresis with marked hypokalemia, hyponatremia, hypomagnesemia, volume depletion and kidney injury.
Ce que signifie cette interaction, en termes simples
Azilsartan-chlorthalidone and Ethacrynic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azilsartan-chlorthalidone belongs to Cardiovascular; Ethacrynic acid belongs to Cardiovascular.
Pourquoi elle survient
Sequential blockade of sodium reabsorption in the loop of Henle and distal tubule produces synergistic natriuresis and potassium wasting.
Conduite à tenir
Start with low doses and monitor weight, blood pressure, electrolytes and renal function closely. Replace potassium and magnesium as needed.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Azilsartan-chlorthalidone
- Aliskiren + Azilsartan-chlorthalidone Contre-indiquée
- Azilsartan-chlorthalidone + Sparsentan Contre-indiquée
- Aceclofenac + Azilsartan-chlorthalidone Majeure
- Aldesleukin + Azilsartan-chlorthalidone Majeure
- Amifostine + Azilsartan-chlorthalidone Majeure
- Azilsartan-chlorthalidone + Benazepril Majeure
Autres interactions de Ethacrynic acid
Questions fréquentes
Can I take Azilsartan-chlorthalidone with Ethacrynic acid?
MediHelp rates the interaction as major. Azilsartan-chlorthalidone and Ethacrynic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ethacrynic acid is a potent loop diuretic and combining it with a thiazide-like diuretic produces sequential nephron blockade. This can cause profound diuresis with marked hypokalemia, hyponatremia, hypomagnesemia, volume depletion and kidney injury.
How serious is the interaction between Azilsartan-chlorthalidone and Ethacrynic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and monitor weight, blood pressure, electrolytes and renal function closely. Replace potassium and magnesium as needed.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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