Interactions médicamenteuses
Enalapril-hydrochlorothiazide + Ethacrynic acid
Gravité: Majeure
Enalapril-hydrochlorothiazide and Ethacrynic acid: major interaction.
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Résumé
Ethacrynic acid is a potent loop diuretic that adds to the thiazide's sodium, water and potassium losses. With enalapril, the resulting volume depletion can cause marked hypotension and acute kidney injury, plus hypokalemia and hypomagnesemia.
Ce que signifie cette interaction, en termes simples
Enalapril-hydrochlorothiazide and Ethacrynic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Ethacrynic acid belongs to Cardiovascular.
Pourquoi elle survient
Sequential nephron blockade with additive diuresis and electrolyte loss, combined with ACE inhibitor reduction of angiotensin II-dependent glomerular perfusion.
Conduite à tenir
Start with low doses and monitor blood pressure, renal function and electrolytes closely, especially in volume-depleted patients. Consider temporarily reducing diuretic doses when starting the combination.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contre-indiquée
- Dofetilide + Enalapril-hydrochlorothiazide Contre-indiquée
- Enalapril-hydrochlorothiazide + Protein a column Contre-indiquée
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contre-indiquée
- Amifostine + Enalapril-hydrochlorothiazide Majeure
- Amiloride + Enalapril-hydrochlorothiazide Majeure
Autres interactions de Ethacrynic acid
Questions fréquentes
Can I take Enalapril-hydrochlorothiazide with Ethacrynic acid?
MediHelp rates the interaction as major. Enalapril-hydrochlorothiazide and Ethacrynic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ethacrynic acid is a potent loop diuretic that adds to the thiazide's sodium, water and potassium losses. With enalapril, the resulting volume depletion can cause marked hypotension and acute kidney injury, plus hypokalemia and hypomagnesemia.
How serious is the interaction between Enalapril-hydrochlorothiazide and Ethacrynic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and monitor blood pressure, renal function and electrolytes closely, especially in volume-depleted patients. Consider temporarily reducing diuretic doses when starting the combination.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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