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Interactions médicamenteuses

Baricitinib + Penicillin g procaine-penicillin g

Gravité: Modérée

Baricitinib and Penicillin g procaine-penicillin g: moderate interaction.

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Résumé

Penicillin G is eliminated by renal tubular secretion and can inhibit OAT3, the transporter involved in baricitinib clearance. This may raise baricitinib exposure, although the clinical effect is probably modest.

Ce que signifie cette interaction, en termes simples

Baricitinib and Penicillin g procaine-penicillin g can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Baricitinib belongs to Musculoskeletal; Penicillin g procaine-penicillin g belongs to Anti Bacterial.

Niveau de preuve: Low

Pourquoi elle survient

Inhibition of renal OAT3-mediated tubular secretion of baricitinib by penicillin G reduces its elimination.

Conduite à tenir

Monitor for baricitinib adverse effects such as infection and cytopenias during penicillin courses. Dose reduction is generally not needed for short courses of penicillin.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Baricitinib with Penicillin g procaine-penicillin g?

MediHelp rates the interaction as moderate. Baricitinib and Penicillin g procaine-penicillin g can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Penicillin G is eliminated by renal tubular secretion and can inhibit OAT3, the transporter involved in baricitinib clearance. This may raise baricitinib exposure, although the clinical effect is probably modest.

How serious is the interaction between Baricitinib and Penicillin g procaine-penicillin g?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for baricitinib adverse effects such as infection and cytopenias during penicillin courses. Dose reduction is generally not needed for short courses of penicillin.

What other medicines interact with Penicillin g procaine-penicillin g?

MediHelp also lists interactions of Penicillin g procaine-penicillin g with, for example, Amifampridine, Cholera vaccine, Microbiota. The full list is on the Penicillin g procaine-penicillin g page.

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