Drug interactions
Baricitinib + Penicillin g procaine-penicillin g
Severity: Moderate
Baricitinib and Penicillin g procaine-penicillin g: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Penicillin G is eliminated by renal tubular secretion and can inhibit OAT3, the transporter involved in baricitinib clearance. This may raise baricitinib exposure, although the clinical effect is probably modest.
What this interaction means in plain words
Baricitinib and Penicillin g procaine-penicillin g can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baricitinib belongs to Musculoskeletal; Penicillin g procaine-penicillin g belongs to Anti Bacterial.
Why it happens
Inhibition of renal OAT3-mediated tubular secretion of baricitinib by penicillin G reduces its elimination.
What to do
Monitor for baricitinib adverse effects such as infection and cytopenias during penicillin courses. Dose reduction is generally not needed for short courses of penicillin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Penicillin g procaine-penicillin g
- Amifampridine + Penicillin g procaine-penicillin g Moderate
- Cholera vaccine + Penicillin g procaine-penicillin g Moderate
- Microbiota + Penicillin g procaine-penicillin g Moderate
- Omadacycline + Penicillin g procaine-penicillin g Moderate
- Penicillin g procaine-penicillin g + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
- Penicillin g procaine-penicillin g + Vadadustat Moderate
Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Frequently asked questions
Can I take Baricitinib with Penicillin g procaine-penicillin g?
MediHelp rates the interaction as moderate. Baricitinib and Penicillin g procaine-penicillin g can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Penicillin G is eliminated by renal tubular secretion and can inhibit OAT3, the transporter involved in baricitinib clearance. This may raise baricitinib exposure, although the clinical effect is probably modest.
How serious is the interaction between Baricitinib and Penicillin g procaine-penicillin g?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for baricitinib adverse effects such as infection and cytopenias during penicillin courses. Dose reduction is generally not needed for short courses of penicillin.
What other medicines interact with Penicillin g procaine-penicillin g?
MediHelp also lists interactions of Penicillin g procaine-penicillin g with, for example, Amifampridine, Cholera vaccine, Microbiota. The full list is on the Penicillin g procaine-penicillin g page.
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