Interactions médicamenteuses
Belzutifan + Ethinyl estradiol-drospirenone
Gravité: Majeure
Belzutifan and Ethinyl estradiol-drospirenone: major interaction.
Dernière mise à jour
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Résumé
Belzutifan can reduce exposure to hormonal contraceptives, which may cause contraceptive failure or breakthrough bleeding. This matters because belzutifan can cause fetal harm.
Ce que signifie cette interaction, en termes simples
Belzutifan and Ethinyl estradiol-drospirenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Belzutifan belongs to Miscellaneous; Ethinyl estradiol-drospirenone belongs to Endocrine.
Pourquoi elle survient
Belzutifan induces CYP3A4, increasing metabolism of ethinyl estradiol and drospirenone.
Conduite à tenir
Use an effective non-hormonal contraceptive method during treatment and for the period specified in labeling after the last dose. Do not rely on hormonal contraception alone.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contre-indiquée
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contre-indiquée
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contre-indiquée
- Ethinyl estradiol-drospirenone + Tranexamic acid Contre-indiquée
- Aminocaproic acid + Ethinyl estradiol-drospirenone Majeure
- Amobarbital + Ethinyl estradiol-drospirenone Majeure
Autres interactions de Belzutifan
Questions fréquentes
Can I take Belzutifan with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as major. Belzutifan and Ethinyl estradiol-drospirenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Belzutifan can reduce exposure to hormonal contraceptives, which may cause contraceptive failure or breakthrough bleeding. This matters because belzutifan can cause fetal harm.
How serious is the interaction between Belzutifan and Ethinyl estradiol-drospirenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an effective non-hormonal contraceptive method during treatment and for the period specified in labeling after the last dose. Do not rely on hormonal contraception alone.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
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