Interactions médicamenteuses
Belzutifan + Cyclosporin
Gravité: Majeure
Belzutifan and Cyclosporin: major interaction.
Dernière mise à jour
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Résumé
Belzutifan induces UGT2B17 and CYP3A4 and can lower exposure to sensitive CYP3A4 substrates such as cyclosporine. Reduced cyclosporine levels may lead to subtherapeutic immunosuppression and a risk of rejection or graft-versus-host disease.
Ce que signifie cette interaction, en termes simples
Belzutifan and Cyclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Belzutifan belongs to Miscellaneous; Cyclosporin belongs to Miscellaneous.
Pourquoi elle survient
Belzutifan induces CYP3A4, increasing cyclosporine metabolism and lowering its blood concentrations.
Conduite à tenir
Monitor cyclosporine trough concentrations closely when starting or stopping belzutifan and adjust the dose as needed. Consider an alternative to belzutifan if levels cannot be maintained.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contre-indiquée
- Aliskiren + Cyclosporin Contre-indiquée
- Bcg vaccine live + Cyclosporin Contre-indiquée
- Bosentan + Cyclosporin Contre-indiquée
- Cidofovir + Cyclosporin Contre-indiquée
- Cyclosporin + Dengue vaccine Contre-indiquée
Autres interactions de Belzutifan
Questions fréquentes
Can I take Belzutifan with Cyclosporin?
MediHelp rates the interaction as major. Belzutifan and Cyclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Belzutifan induces UGT2B17 and CYP3A4 and can lower exposure to sensitive CYP3A4 substrates such as cyclosporine. Reduced cyclosporine levels may lead to subtherapeutic immunosuppression and a risk of rejection or graft-versus-host disease.
How serious is the interaction between Belzutifan and Cyclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough concentrations closely when starting or stopping belzutifan and adjust the dose as needed. Consider an alternative to belzutifan if levels cannot be maintained.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
