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Interactions médicamenteuses

Benazepril + Bismuth subsalicylate

Gravité: Modérée

Benazepril and Bismuth subsalicylate: moderate interaction.

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Résumé

Salicylate absorbed from bismuth subsalicylate can blunt the blood pressure lowering effect of ACE inhibitors and may add to renal risk, especially in volume depletion, such as during diarrhea. Acute kidney injury is a concern in dehydrated or older patients.

Ce que signifie cette interaction, en termes simples

Benazepril and Bismuth subsalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Benazepril belongs to Cardiovascular; Bismuth subsalicylate belongs to Gastrointestinal Tract.

Niveau de preuve: Moderate

Pourquoi elle survient

Salicylate-mediated inhibition of renal prostaglandins reduces vasodilation and renal perfusion, antagonizing ACE inhibitor effects.

Conduite à tenir

Avoid regular or prolonged use of bismuth subsalicylate. In dehydrated patients monitor renal function, potassium and blood pressure.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Benazepril with Bismuth subsalicylate?

MediHelp rates the interaction as moderate. Benazepril and Bismuth subsalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylate absorbed from bismuth subsalicylate can blunt the blood pressure lowering effect of ACE inhibitors and may add to renal risk, especially in volume depletion, such as during diarrhea. Acute kidney injury is a concern in dehydrated or older patients.

How serious is the interaction between Benazepril and Bismuth subsalicylate?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular or prolonged use of bismuth subsalicylate. In dehydrated patients monitor renal function, potassium and blood pressure.

What other medicines interact with Bismuth subsalicylate?

MediHelp also lists interactions of Bismuth subsalicylate with, for example, Dichlorphenamide, Warfarin, Acetylsalicylic acid. The full list is on the Bismuth subsalicylate page.

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