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Interactions médicamenteuses

Blinatumomab + Phenytoin

Gravité: Modérée

Blinatumomab and Phenytoin: moderate interaction.

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Résumé

Blinatumomab causes a transient cytokine release at treatment start that can suppress CYP450 enzymes. Phenytoin has a narrow therapeutic index, so levels may rise and cause toxicity such as ataxia, nystagmus or confusion.

Ce que signifie cette interaction, en termes simples

Blinatumomab and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Blinatumomab belongs to Oncology; Phenytoin belongs to Central Nervous System.

Niveau de preuve: Low

Pourquoi elle survient

Cytokine release from blinatumomab transiently suppresses CYP450 metabolism of phenytoin.

Conduite à tenir

Monitor phenytoin levels and signs of toxicity, particularly in the first days of the first cycle and early in the second cycle. Adjust the phenytoin dose according to levels.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Blinatumomab with Phenytoin?

MediHelp rates the interaction as moderate. Blinatumomab and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Blinatumomab causes a transient cytokine release at treatment start that can suppress CYP450 enzymes. Phenytoin has a narrow therapeutic index, so levels may rise and cause toxicity such as ataxia, nystagmus or confusion.

How serious is the interaction between Blinatumomab and Phenytoin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor phenytoin levels and signs of toxicity, particularly in the first days of the first cycle and early in the second cycle. Adjust the phenytoin dose according to levels.

What other medicines interact with Phenytoin?

MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.

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