Interactions médicamenteuses
Blinatumomab + Quinine
Gravité: Modérée
Blinatumomab and Quinine: moderate interaction.
Dernière mise à jour
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Résumé
Blinatumomab causes a transient cytokine release at the start of treatment that may suppress CYP450 enzyme activity. This could temporarily raise quinine concentrations, which matters because quinine has a narrow therapeutic window and cardiac toxicity.
Ce que signifie cette interaction, en termes simples
Blinatumomab and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Blinatumomab belongs to Oncology; Quinine belongs to Anti Parasitic.
Pourquoi elle survient
Cytokine-mediated transient suppression of CYP450 enzymes (including CYP3A4) reducing quinine metabolism.
Conduite à tenir
Monitor for quinine toxicity (tinnitus, QT prolongation, hypoglycemia) during the first days of the first cycle and after re-initiation. Consider reducing the quinine dose or monitoring ECG in high-risk patients.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Quinine
- Arsenic trioxide + Quinine Contre-indiquée
- Dofetilide + Quinine Contre-indiquée
- Dronedarone + Quinine Contre-indiquée
- Ibutilide + Quinine Contre-indiquée
- Mefloquine + Quinine Contre-indiquée
- Nilotinib + Quinine Contre-indiquée
Autres interactions de Blinatumomab
- Blinatumomab + Carbamazepine Modérée
- Blinatumomab + Cyclosporin Modérée
- Blinatumomab + Ethosuximide Modérée
- Blinatumomab + Phenytoin Modérée
- Blinatumomab + Quinidine Modérée
- Blinatumomab + Siponimod Modérée
Questions fréquentes
Can I take Blinatumomab with Quinine?
MediHelp rates the interaction as moderate. Blinatumomab and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Blinatumomab causes a transient cytokine release at the start of treatment that may suppress CYP450 enzyme activity. This could temporarily raise quinine concentrations, which matters because quinine has a narrow therapeutic window and cardiac toxicity.
How serious is the interaction between Blinatumomab and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for quinine toxicity (tinnitus, QT prolongation, hypoglycemia) during the first days of the first cycle and after re-initiation. Consider reducing the quinine dose or monitoring ECG in high-risk patients.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
