Interactions médicamenteuses
Bosutinib + Clotrimazole
Gravité: Modérée
Bosutinib and Clotrimazole: moderate interaction.
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Résumé
Systemic clotrimazole exposure is low with topical or local use, but oral lozenge use can inhibit CYP3A4 and potentially raise bosutinib levels. Higher bosutinib exposure could increase gastrointestinal, hepatic and myelosuppressive toxicity.
Ce que signifie cette interaction, en termes simples
Bosutinib and Clotrimazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Clotrimazole belongs to Anti Fungals.
Pourquoi elle survient
Clotrimazole is a CYP3A4 inhibitor that may reduce bosutinib metabolism.
Conduite à tenir
Prefer topical or vaginal forms, or an alternative antifungal if systemic exposure is expected. Monitor for bosutinib toxicity and liver enzymes if combined.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Clotrimazole
- Clotrimazole + Lomitapide Majeure
- Clotrimazole + Mavacamten Majeure
- Clotrimazole + Mobocertinib Majeure
- Clotrimazole + Voclosporin Majeure
- Cannabidiol + Clotrimazole Modérée
- Clotrimazole + Cyclosporine Modérée
Autres interactions de Bosutinib
- Amiodarone + Bosutinib Majeure
- Apalutamide + Bosutinib Majeure
- Aprepitant + Bosutinib Majeure
- Bosentan + Bosutinib Majeure
- Bosutinib + Carbamazepine Majeure
- Bosutinib + Chlorpromazine Majeure
Questions fréquentes
Can I take Bosutinib with Clotrimazole?
MediHelp rates the interaction as moderate. Bosutinib and Clotrimazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic clotrimazole exposure is low with topical or local use, but oral lozenge use can inhibit CYP3A4 and potentially raise bosutinib levels. Higher bosutinib exposure could increase gastrointestinal, hepatic and myelosuppressive toxicity.
How serious is the interaction between Bosutinib and Clotrimazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer topical or vaginal forms, or an alternative antifungal if systemic exposure is expected. Monitor for bosutinib toxicity and liver enzymes if combined.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mavacamten, Mobocertinib. The full list is on the Clotrimazole page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
