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Interactions médicamenteuses

Clotrimazole + Lomitapide

Gravité: Majeure

Clotrimazole and Lomitapide: major interaction.

Dernière mise à jour

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Résumé

Lomitapide is extensively metabolized by CYP3A4, and strong inhibitors raise its exposure many-fold, increasing the risk of hepatotoxicity and gastrointestinal adverse effects. Systemic clotrimazole is a CYP3A4 inhibitor, though topical or oral lozenge use gives limited exposure.

Ce que signifie cette interaction, en termes simples

Clotrimazole and Lomitapide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Clotrimazole belongs to Anti Fungals; Lomitapide belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Clotrimazole inhibits CYP3A4-mediated metabolism of lomitapide, increasing its systemic concentrations.

Conduite à tenir

Avoid systemic or prolonged clotrimazole use during lomitapide therapy and choose an antifungal with less CYP3A4 effect. Monitor liver enzymes if exposure cannot be avoided.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Clotrimazole with Lomitapide?

MediHelp rates the interaction as major. Clotrimazole and Lomitapide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lomitapide is extensively metabolized by CYP3A4, and strong inhibitors raise its exposure many-fold, increasing the risk of hepatotoxicity and gastrointestinal adverse effects. Systemic clotrimazole is a CYP3A4 inhibitor, though topical or oral lozenge use gives limited exposure.

How serious is the interaction between Clotrimazole and Lomitapide?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic or prolonged clotrimazole use during lomitapide therapy and choose an antifungal with less CYP3A4 effect. Monitor liver enzymes if exposure cannot be avoided.

What other medicines interact with Clotrimazole?

MediHelp also lists interactions of Clotrimazole with, for example, Mavacamten, Mobocertinib, Voclosporin. The full list is on the Clotrimazole page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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