Interactions médicamenteuses
Cannabidiol + Clotrimazole
Gravité: Modérée
Cannabidiol and Clotrimazole: moderate interaction.
Dernière mise à jour
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Résumé
Systemic clotrimazole exposure (for example from lozenges or troches) may inhibit CYP3A4 and raise cannabidiol concentrations. This could increase sedation, somnolence and liver enzyme elevations. The effect is expected to be modest with topical use.
Ce que signifie cette interaction, en termes simples
Cannabidiol and Clotrimazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Clotrimazole belongs to Anti Fungals.
Pourquoi elle survient
Inhibition of CYP3A4-mediated metabolism of cannabidiol by clotrimazole.
Conduite à tenir
Monitor for excess sedation and check liver enzymes if systemic clotrimazole is used. Consider reducing the cannabidiol dose if adverse effects appear.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Clotrimazole
- Clotrimazole + Lomitapide Majeure
- Clotrimazole + Mavacamten Majeure
- Clotrimazole + Mobocertinib Majeure
- Clotrimazole + Voclosporin Majeure
- Bosutinib + Clotrimazole Modérée
- Clotrimazole + Cyclosporine Modérée
Autres interactions de Cannabidiol
- Cannabidiol + Phenytoin Majeure
- Cannabidiol + Sodium valproate Majeure
- Cannabidiol + Tacrolimus Majeure
- Abiraterone + Cannabidiol Modérée
- Alogliptin-pioglitazone + Cannabidiol Modérée
- Amiodarone + Cannabidiol Modérée
Questions fréquentes
Can I take Cannabidiol with Clotrimazole?
MediHelp rates the interaction as moderate. Cannabidiol and Clotrimazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic clotrimazole exposure (for example from lozenges or troches) may inhibit CYP3A4 and raise cannabidiol concentrations. This could increase sedation, somnolence and liver enzyme elevations. The effect is expected to be modest with topical use.
How serious is the interaction between Cannabidiol and Clotrimazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and check liver enzymes if systemic clotrimazole is used. Consider reducing the cannabidiol dose if adverse effects appear.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mavacamten, Mobocertinib. The full list is on the Clotrimazole page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
