Interactions médicamenteuses
Bosutinib + Cyclosporin
Gravité: Majeure
Bosutinib and Cyclosporin: major interaction.
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Résumé
Cyclosporine inhibits CYP3A4 and P-glycoprotein and may raise bosutinib concentrations, increasing the risk of gastrointestinal toxicity, hepatotoxicity and myelosuppression.
Ce que signifie cette interaction, en termes simples
Bosutinib and Cyclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosutinib belongs to Oncology; Cyclosporin belongs to Miscellaneous.
Pourquoi elle survient
Inhibition of CYP3A4 metabolism and P-gp efflux of bosutinib.
Conduite à tenir
Avoid the combination where possible. If needed, monitor liver tests, blood counts and bosutinib adverse effects, with dose reduction as needed.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contre-indiquée
- Aliskiren + Cyclosporin Contre-indiquée
- Bcg vaccine live + Cyclosporin Contre-indiquée
- Bosentan + Cyclosporin Contre-indiquée
- Cidofovir + Cyclosporin Contre-indiquée
- Cyclosporin + Dengue vaccine Contre-indiquée
Autres interactions de Bosutinib
- Amiodarone + Bosutinib Majeure
- Apalutamide + Bosutinib Majeure
- Aprepitant + Bosutinib Majeure
- Bosentan + Bosutinib Majeure
- Bosutinib + Carbamazepine Majeure
- Bosutinib + Chlorpromazine Majeure
Questions fréquentes
Can I take Bosutinib with Cyclosporin?
MediHelp rates the interaction as major. Bosutinib and Cyclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine inhibits CYP3A4 and P-glycoprotein and may raise bosutinib concentrations, increasing the risk of gastrointestinal toxicity, hepatotoxicity and myelosuppression.
How serious is the interaction between Bosutinib and Cyclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If needed, monitor liver tests, blood counts and bosutinib adverse effects, with dose reduction as needed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
