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Interactions médicamenteuses

Brexpiprazole + Dacomitinib

Gravité: Majeure

Brexpiprazole and Dacomitinib: major interaction.

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Résumé

Dacomitinib strongly inhibits CYP2D6, one of the two main enzymes that clear brexpiprazole, so brexpiprazole levels can rise. This increases the risk of dose-related adverse effects such as akathisia, sedation and orthostasis.

Ce que signifie cette interaction, en termes simples

Brexpiprazole and Dacomitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Brexpiprazole belongs to Central Nervous System; Dacomitinib belongs to Oncology.

Niveau de preuve: Moderate

Pourquoi elle survient

Inhibition of CYP2D6-mediated metabolism of brexpiprazole by dacomitinib.

Conduite à tenir

Reduce the brexpiprazole dose to about half while dacomitinib is given, and monitor for adverse effects; restore the usual dose after dacomitinib is stopped and its effect has waned.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

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Questions fréquentes

Can I take Brexpiprazole with Dacomitinib?

MediHelp rates the interaction as major. Brexpiprazole and Dacomitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dacomitinib strongly inhibits CYP2D6, one of the two main enzymes that clear brexpiprazole, so brexpiprazole levels can rise. This increases the risk of dose-related adverse effects such as akathisia, sedation and orthostasis.

How serious is the interaction between Brexpiprazole and Dacomitinib?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the brexpiprazole dose to about half while dacomitinib is given, and monitor for adverse effects; restore the usual dose after dacomitinib is stopped and its effect has waned.

What other medicines interact with Brexpiprazole?

MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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