Aller au contenu
MediHelp
MediHelp Référence médicamenteuse

Interactions médicamenteuses

Clomipramine + Dacomitinib

Gravité: Majeure

Clomipramine and Dacomitinib: major interaction.

Dernière mise à jour

Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.

Le contenu clinique de cette page n'est disponible qu'en anglais.

Résumé

Dacomitinib is a strong inhibitor of CYP2D6, an enzyme that contributes to clomipramine clearance, particularly of its active metabolite pathway. Clomipramine exposure may rise, increasing anticholinergic effects, sedation, seizure risk and cardiac conduction toxicity.

Ce que signifie cette interaction, en termes simples

Clomipramine and Dacomitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Clomipramine belongs to Central Nervous System; Dacomitinib belongs to Oncology.

Niveau de preuve: Moderate

Pourquoi elle survient

Dacomitinib inhibits CYP2D6, reducing the hydroxylation and clearance of clomipramine.

Conduite à tenir

Consider an alternative to one of the drugs; if combined, start clomipramine at a low dose and titrate to response. Monitor for tricyclic toxicity and consider ECG and plasma level monitoring.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Réservé aux membres Pro+

Débloquer la page complète

Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Clomipramine et Dacomitinib, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
Créer un compte gratuit Se connecter

Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.

Questions fréquentes

Can I take Clomipramine with Dacomitinib?

MediHelp rates the interaction as major. Clomipramine and Dacomitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dacomitinib is a strong inhibitor of CYP2D6, an enzyme that contributes to clomipramine clearance, particularly of its active metabolite pathway. Clomipramine exposure may rise, increasing anticholinergic effects, sedation, seizure risk and cardiac conduction toxicity.

How serious is the interaction between Clomipramine and Dacomitinib?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative to one of the drugs; if combined, start clomipramine at a low dose and titrate to response. Monitor for tricyclic toxicity and consider ECG and plasma level monitoring.

What other medicines interact with Clomipramine?

MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

Télécharger surApp Store Disponible surGoogle Play

Parcourir de A à Z · Interactions médicamenteuses

Télécharger l'app Se connecter