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Interactions médicamenteuses

Dacomitinib + Desipramine

Gravité: Majeure

Dacomitinib and Desipramine: major interaction.

Dernière mise à jour

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Résumé

Dacomitinib is a strong CYP2D6 inhibitor, and desipramine is cleared mainly via CYP2D6. Desipramine exposure can rise markedly, increasing the risk of anticholinergic effects, cardiac conduction abnormalities and arrhythmia.

Ce que signifie cette interaction, en termes simples

Dacomitinib and Desipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Dacomitinib belongs to Oncology; Desipramine belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Dacomitinib inhibits CYP2D6, reducing the metabolism of desipramine.

Conduite à tenir

Avoid the combination if possible. If used, reduce the desipramine dose guided by plasma levels and ECG monitoring, and watch for toxicity.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Dacomitinib with Desipramine?

MediHelp rates the interaction as major. Dacomitinib and Desipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dacomitinib is a strong CYP2D6 inhibitor, and desipramine is cleared mainly via CYP2D6. Desipramine exposure can rise markedly, increasing the risk of anticholinergic effects, cardiac conduction abnormalities and arrhythmia.

How serious is the interaction between Dacomitinib and Desipramine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If used, reduce the desipramine dose guided by plasma levels and ECG monitoring, and watch for toxicity.

What other medicines interact with Desipramine?

MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.

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