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Interactions médicamenteuses

Brigatinib + Ethinyl estradiol-drospirenone

Gravité: Majeure

Brigatinib and Ethinyl estradiol-drospirenone: major interaction.

Dernière mise à jour

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Résumé

Brigatinib may induce CYP3A4 and reduce hormone exposure from contraceptives, risking contraceptive failure. Pregnancy during brigatinib treatment is a concern because of fetal harm.

Ce que signifie cette interaction, en termes simples

Brigatinib and Ethinyl estradiol-drospirenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Brigatinib belongs to Oncology; Ethinyl estradiol-drospirenone belongs to Endocrine.

Niveau de preuve: Moderate

Pourquoi elle survient

Brigatinib induces CYP3A4, accelerating metabolism of ethinyl estradiol and drospirenone.

Conduite à tenir

Use an effective non-hormonal contraceptive during treatment and for the period specified in labeling after the last dose.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Brigatinib with Ethinyl estradiol-drospirenone?

MediHelp rates the interaction as major. Brigatinib and Ethinyl estradiol-drospirenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brigatinib may induce CYP3A4 and reduce hormone exposure from contraceptives, risking contraceptive failure. Pregnancy during brigatinib treatment is a concern because of fetal harm.

How serious is the interaction between Brigatinib and Ethinyl estradiol-drospirenone?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an effective non-hormonal contraceptive during treatment and for the period specified in labeling after the last dose.

What other medicines interact with Ethinyl estradiol-drospirenone?

MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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