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Interactions médicamenteuses

Caffeine + Ciprofloxacin

Gravité: Modérée

Caffeine and Ciprofloxacin: moderate interaction.

Dernière mise à jour

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Résumé

Ciprofloxacin reduces the clearance of caffeine, prolonging its half-life and raising plasma concentrations. Patients may experience jitteriness, insomnia, tachycardia, palpitations or headache, particularly with high caffeine intake.

Ce que signifie cette interaction, en termes simples

Caffeine and Ciprofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Caffeine belongs to Miscellaneous; Ciprofloxacin belongs to Anti Bacterial.

Niveau de preuve: High

Pourquoi elle survient

Ciprofloxacin inhibits CYP1A2, the main enzyme responsible for caffeine metabolism.

Conduite à tenir

Advise patients to limit caffeinated drinks and products during ciprofloxacin therapy. Reassess if symptoms such as palpitations, tremor or insomnia occur.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Caffeine with Ciprofloxacin?

MediHelp rates the interaction as moderate. Caffeine and Ciprofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ciprofloxacin reduces the clearance of caffeine, prolonging its half-life and raising plasma concentrations. Patients may experience jitteriness, insomnia, tachycardia, palpitations or headache, particularly with high caffeine intake.

How serious is the interaction between Caffeine and Ciprofloxacin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to limit caffeinated drinks and products during ciprofloxacin therapy. Reassess if symptoms such as palpitations, tremor or insomnia occur.

What other medicines interact with Ciprofloxacin?

MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.

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