Interactions médicamenteuses
Caffeine + Fezolinetant
Gravité: Majeure
Caffeine and Fezolinetant: major interaction.
Dernière mise à jour
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Résumé
Fezolinetant is cleared mainly by CYP1A2, and caffeine is a CYP1A2 substrate that can compete for this enzyme. Reduced clearance could raise fezolinetant exposure and increase the risk of adverse effects including liver injury. The labeled contraindication concerns CYP1A2 inhibitors; ordinary dietary caffeine is a weak interaction, but it is flagged here.
Ce que signifie cette interaction, en termes simples
Caffeine and Fezolinetant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Caffeine belongs to Miscellaneous; Fezolinetant belongs to Endocrine.
Pourquoi elle survient
Competition for CYP1A2 metabolism may reduce fezolinetant clearance and increase its plasma concentrations.
Conduite à tenir
Counsel patients to limit caffeine intake, especially high doses or caffeine-containing medicines, during fezolinetant therapy. Monitor liver tests per fezolinetant labeling and for adverse effects.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Caffeine
- Caffeine + Ephedrine Majeure
- Caffeine + Methylenedioxymethamphetamine Majeure
- Caffeine + Selegiline transdermal Majeure
- Adenosine + Caffeine Modérée
- Benzphetamine + Caffeine Modérée
- Caffeine + Ciprofloxacin Modérée
Autres interactions de Fezolinetant
- Cimetidine + Fezolinetant Contre-indiquée
- Ciprofloxacin + Fezolinetant Contre-indiquée
- Desogestrel-ethinyl estradiol + Fezolinetant Contre-indiquée
- Estradiol + Fezolinetant Contre-indiquée
- Ethinyl estradiol-drospirenone + Fezolinetant Contre-indiquée
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contre-indiquée
Questions fréquentes
Can I take Caffeine with Fezolinetant?
MediHelp rates the interaction as major. Caffeine and Fezolinetant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fezolinetant is cleared mainly by CYP1A2, and caffeine is a CYP1A2 substrate that can compete for this enzyme. Reduced clearance could raise fezolinetant exposure and increase the risk of adverse effects including liver injury. The labeled contraindication concerns CYP1A2 inhibitors; ordinary dietary caffeine is a weak interaction, but it is flagged here.
How serious is the interaction between Caffeine and Fezolinetant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to limit caffeine intake, especially high doses or caffeine-containing medicines, during fezolinetant therapy. Monitor liver tests per fezolinetant labeling and for adverse effects.
What other medicines interact with Caffeine?
MediHelp also lists interactions of Caffeine with, for example, Ephedrine, Methylenedioxymethamphetamine, Selegiline transdermal. The full list is on the Caffeine page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
