Aller au contenu
MediHelp
MediHelp Référence médicamenteuse

Interactions médicamenteuses

Carbamazepine + Mavacamten

Gravité: Contre-indiquée

Carbamazepine and Mavacamten: contraindicated interaction.

Dernière mise à jour

Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.

Le contenu clinique de cette page n'est disponible qu'en anglais.

Résumé

Carbamazepine markedly reduces mavacamten exposure, which may cause loss of efficacy in obstructive hypertrophic cardiomyopathy. Stopping the inducer later could also cause mavacamten levels to rise unexpectedly.

Ce que signifie cette interaction, en termes simples

Carbamazepine and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Carbamazepine belongs to Central Nervous System; Mavacamten belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

Carbamazepine induces CYP2C19 and CYP3A4, the main enzymes clearing mavacamten.

Conduite à tenir

Avoid the combination as labeled. If an inducer is stopped or started, reassess LVEF and gradients and adjust mavacamten dose by echocardiography.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Réservé aux membres Pro+

Débloquer la page complète

Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Carbamazepine et Mavacamten, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
Créer un compte gratuit Se connecter

Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.

Questions fréquentes

Can I take Carbamazepine with Mavacamten?

MediHelp rates the interaction as contraindicated. Carbamazepine and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Carbamazepine markedly reduces mavacamten exposure, which may cause loss of efficacy in obstructive hypertrophic cardiomyopathy. Stopping the inducer later could also cause mavacamten levels to rise unexpectedly.

How serious is the interaction between Carbamazepine and Mavacamten?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination as labeled. If an inducer is stopped or started, reassess LVEF and gradients and adjust mavacamten dose by echocardiography.

What other medicines interact with Carbamazepine?

MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

Télécharger surApp Store Disponible surGoogle Play

Parcourir de A à Z · Interactions médicamenteuses

Télécharger l'app Se connecter