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Interactions médicamenteuses

Enzalutamide + Mavacamten

Gravité: Contre-indiquée

Enzalutamide and Mavacamten: contraindicated interaction.

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Résumé

Mavacamten is cleared by CYP2C19 and CYP3A4, and enzalutamide induces both, lowering exposure and reducing therapeutic effect on outflow obstruction. Labeling advises against use with strong inducers of these enzymes.

Ce que signifie cette interaction, en termes simples

Enzalutamide and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Enzalutamide belongs to Endocrine; Mavacamten belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Induction of CYP2C19 and CYP3A4 by enzalutamide increases mavacamten clearance.

Conduite à tenir

Avoid the combination; if enzalutamide is started or stopped in a mavacamten patient, check LVEF and gradient by echocardiography and adjust the dose.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Enzalutamide with Mavacamten?

MediHelp rates the interaction as contraindicated. Enzalutamide and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mavacamten is cleared by CYP2C19 and CYP3A4, and enzalutamide induces both, lowering exposure and reducing therapeutic effect on outflow obstruction. Labeling advises against use with strong inducers of these enzymes.

How serious is the interaction between Enzalutamide and Mavacamten?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if enzalutamide is started or stopped in a mavacamten patient, check LVEF and gradient by echocardiography and adjust the dose.

What other medicines interact with Enzalutamide?

MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.

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