Aller au contenu
MediHelp
MediHelp Référence médicamenteuse

Interactions médicamenteuses

Clarithromycin + Mavacamten

Gravité: Contre-indiquée

Clarithromycin and Mavacamten: contraindicated interaction.

Dernière mise à jour

Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.

Le contenu clinique de cette page n'est disponible qu'en anglais.

Résumé

Clarithromycin may substantially increase mavacamten exposure, which can excessively reduce left ventricular ejection fraction and cause heart failure from systolic dysfunction. Strong CYP3A4 inhibitors are contraindicated in the labeling.

Ce que signifie cette interaction, en termes simples

Clarithromycin and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Clarithromycin belongs to Anti Bacterial; Mavacamten belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

Clarithromycin inhibits CYP3A4 (and CYP2C19 contributions) and thereby reduces mavacamten clearance.

Conduite à tenir

Do not coadminister; use an alternative antibiotic such as azithromycin and monitor LVEF if exposure occurs.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Réservé aux membres Pro+

Débloquer la page complète

Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Clarithromycin et Mavacamten, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
Créer un compte gratuit Se connecter

Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.

Questions fréquentes

Can I take Clarithromycin with Mavacamten?

MediHelp rates the interaction as contraindicated. Clarithromycin and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin may substantially increase mavacamten exposure, which can excessively reduce left ventricular ejection fraction and cause heart failure from systolic dysfunction. Strong CYP3A4 inhibitors are contraindicated in the labeling.

How serious is the interaction between Clarithromycin and Mavacamten?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative antibiotic such as azithromycin and monitor LVEF if exposure occurs.

What other medicines interact with Clarithromycin?

MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

Télécharger surApp Store Disponible surGoogle Play

Parcourir de A à Z · Interactions médicamenteuses

Télécharger l'app Se connecter