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Interactions médicamenteuses

Carbamazepine + Orlistat

Gravité: Modérée

Carbamazepine and Orlistat: moderate interaction.

Dernière mise à jour

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Résumé

Orlistat has been linked to reduced antiepileptic levels and breakthrough seizures in case reports, including with carbamazepine. Loss of seizure control could be serious.

Ce que signifie cette interaction, en termes simples

Carbamazepine and Orlistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Carbamazepine belongs to Central Nervous System; Orlistat belongs to Miscellaneous.

Niveau de preuve: Low

Pourquoi elle survient

Orlistat may reduce carbamazepine absorption from the gut; the mechanism is not firmly established.

Conduite à tenir

Monitor carbamazepine levels and seizure frequency when orlistat is started or stopped. Consider avoiding orlistat in patients with poorly controlled epilepsy.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Carbamazepine with Orlistat?

MediHelp rates the interaction as moderate. Carbamazepine and Orlistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orlistat has been linked to reduced antiepileptic levels and breakthrough seizures in case reports, including with carbamazepine. Loss of seizure control could be serious.

How serious is the interaction between Carbamazepine and Orlistat?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor carbamazepine levels and seizure frequency when orlistat is started or stopped. Consider avoiding orlistat in patients with poorly controlled epilepsy.

What other medicines interact with Carbamazepine?

MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.

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