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Interactions médicamenteuses

Cholecalciferol + Orlistat

Gravité: Modérée

Cholecalciferol and Orlistat: moderate interaction.

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Résumé

Orlistat blocks dietary fat digestion and thereby reduces absorption of fat-soluble vitamins, including vitamin D. Long-term use can lower vitamin D levels.

Ce que signifie cette interaction, en termes simples

Cholecalciferol and Orlistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Cholecalciferol belongs to Musculoskeletal; Orlistat belongs to Miscellaneous.

Niveau de preuve: High

Pourquoi elle survient

Inhibition of gastrointestinal lipases reduces fat absorption and micellar solubilization of fat-soluble vitamins.

Conduite à tenir

Take vitamin D at least 2 hours before or after orlistat, for example at bedtime. Monitor 25-hydroxyvitamin D levels and adjust the dose as needed.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cholecalciferol with Orlistat?

MediHelp rates the interaction as moderate. Cholecalciferol and Orlistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orlistat blocks dietary fat digestion and thereby reduces absorption of fat-soluble vitamins, including vitamin D. Long-term use can lower vitamin D levels.

How serious is the interaction between Cholecalciferol and Orlistat?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take vitamin D at least 2 hours before or after orlistat, for example at bedtime. Monitor 25-hydroxyvitamin D levels and adjust the dose as needed.

What other medicines interact with Cholecalciferol?

MediHelp also lists interactions of Cholecalciferol with, for example, Digoxin, Aluminum hydroxide, Calcium acetate. The full list is on the Cholecalciferol page.

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