Interactions médicamenteuses
Cyclosporine + Orlistat
Gravité: Majeure
Cyclosporine and Orlistat: major interaction.
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Résumé
Orlistat can lower cyclosporine blood concentrations and has been associated with subtherapeutic levels in transplant recipients. This risks acute rejection if the drop goes unnoticed.
Ce que signifie cette interaction, en termes simples
Cyclosporine and Orlistat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Orlistat reduces dietary fat absorption and may impair absorption of the highly lipophilic cyclosporine from the gut.
Conduite à tenir
Avoid the combination where possible; if used, monitor cyclosporine trough levels closely and adjust the dose. Give cyclosporine at least 3 hours apart from orlistat.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Orlistat
- Cyclosporin + Orlistat Majeure
- Orlistat + Triheptanoin Majeure
- Amiodarone + Orlistat Modérée
- Beta carotene + Orlistat Modérée
- Carbamazepine + Orlistat Modérée
- Cholecalciferol + Orlistat Modérée
Questions fréquentes
Can I take Cyclosporine with Orlistat?
MediHelp rates the interaction as major. Cyclosporine and Orlistat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Orlistat can lower cyclosporine blood concentrations and has been associated with subtherapeutic levels in transplant recipients. This risks acute rejection if the drop goes unnoticed.
How serious is the interaction between Cyclosporine and Orlistat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor cyclosporine trough levels closely and adjust the dose. Give cyclosporine at least 3 hours apart from orlistat.
What other medicines interact with Orlistat?
MediHelp also lists interactions of Orlistat with, for example, Cyclosporin, Triheptanoin, Amiodarone. The full list is on the Orlistat page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
