Référentiel des médicaments
Orlistat
Orlistat is a medicine in the class miscellaneous. It is used for obesity.
- Classe médicamenteuse: Miscellaneous
- Indications: obesity
Dernière mise à jour
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
L'essentiel
- Classe médicamenteuse
- Miscellaneous
- Code ATC
- A08AB01
- Formes courantes
- gélule
- Dosages courants
- 120 mg, 60 mg
- Interactions connues
- 70 (Majeure: 3 · Modérée: 44 · Mineure: 23)
- Noms commerciaux
- 25
- Pays et marchés
- 5
Indications
Mécanisme d'action
Inhibits gastric and pancreatic lipases, prevents triglyceride hydrolysis resulting in decreased absorption of dietary fats
Posologie adulte habituelle (résumé de la notice)
(Xenical): 120 mg PO q8hr with each fat-containing meal (during or up to 1 hr after the meal), doses >120 mg TID show no additional benefit
Grossesse et allaitement
- Grossesse
- Unknown Not for use in pregnancy: weight loss offers no benefit in pregnancy and may harm the fetus (US label contraindication). No embryo toxicity or malformations in animals at high doses. Stop if pregnancy occurs; the EU label advises caution.
- Allaitement
- Safe Very little is absorbed; a small amount was found in one woman's milk. EU label contraindicates breastfeeding (no data); US label: caution. LactMed: unlikely to affect the infant; the mother should take a multivitamin at bedtime because it lowers fat-soluble vitamin absorption.
Effets indésirables signalés
- Flatulence
- Oily spotting
- Fatty/oily stool
- Increased defecation
Précautions particulières
- Daily fat intake (30% of calories), carbohydrate, and protein should be evenly distributed over 3 main meals
- Postmarketing reports of severe liver injury with hepatocellular necrosis or acute hepatic failure with some cases resulting in liver transplant or death
- Some patients may develop increased levels of urinary oxalate following treatment; cases of oxalate nephrolithiasis and oxalate nephropathy with renal failure reported
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (70)
- Cyclosporin + Orlistat Major
- Cyclosporine + Orlistat Major
- Orlistat + Triheptanoin Major
- Amiodarone + Orlistat Moderate
- Beta carotene + Orlistat Moderate
- Carbamazepine + Orlistat Moderate
- Cholecalciferol + Orlistat Moderate
- Clobazam + Orlistat Moderate
- Clonazepam + Orlistat Moderate
- Clorazepate + Orlistat Moderate
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour ouvrir la monographie complète de Orlistat : posologie, grossesse et allaitement, effets indésirables, mises en garde et toutes les interactions.
- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.
Questions fréquentes
What is Orlistat used for?
Orlistat is a medicine in the class miscellaneous. It is used for Obesity.
What side effects have been reported with Orlistat?
Flatulence, Oily spotting, Fatty/oily stool, Increased defecation.
Can Orlistat be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Not for use in pregnancy: weight loss offers no benefit in pregnancy and may harm the fetus (US label contraindication). No embryo toxicity or malformations in animals at high doses. Stop if pregnancy occurs; the EU label advises caution. Breastfeeding: Safe. Very little is absorbed; a small amount was found in one woman's milk. EU label contraindicates breastfeeding (no data); US label: caution. LactMed: unlikely to affect the infant; the mother should take a multivitamin at bedtime because it lowers fat-soluble vitamin absorption.
What does Orlistat interact with?
MediHelp lists 70 known interactions for Orlistat. Major: 3 · Moderate: 44 · Minor: 23. The most serious include Cyclosporin, Cyclosporine, Triheptanoin.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
