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Interactions médicamenteuses

Amiodarone + Orlistat

Gravité: Modérée

Amiodarone and Orlistat: moderate interaction.

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Résumé

Orlistat reduces dietary fat absorption and has been reported to lower absorption of the highly lipophilic amiodarone and its metabolite. Reduced levels could lead to loss of arrhythmia control.

Ce que signifie cette interaction, en termes simples

Amiodarone and Orlistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Amiodarone belongs to Cardiovascular; Orlistat belongs to Miscellaneous.

Niveau de preuve: Low

Pourquoi elle survient

Reduced intestinal absorption of lipophilic amiodarone due to lipase inhibition and reduced fat availability.

Conduite à tenir

Monitor for recurrent arrhythmia and consider checking amiodarone levels; adjust the dose if needed. Avoid starting orlistat without review if rhythm control is tenuous.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amiodarone with Orlistat?

MediHelp rates the interaction as moderate. Amiodarone and Orlistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orlistat reduces dietary fat absorption and has been reported to lower absorption of the highly lipophilic amiodarone and its metabolite. Reduced levels could lead to loss of arrhythmia control.

How serious is the interaction between Amiodarone and Orlistat?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for recurrent arrhythmia and consider checking amiodarone levels; adjust the dose if needed. Avoid starting orlistat without review if rhythm control is tenuous.

What other medicines interact with Amiodarone?

MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.

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