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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Carmustine + Lomustine

Gravité: Majeure

Carmustine and Lomustine: major interaction.

Dernière mise à jour

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Résumé

Both are nitrosoureas with delayed, cumulative myelosuppression and pulmonary toxicity. Using them together increases the risk of profound and prolonged cytopenias and lung injury. There is no therapeutic rationale for combining agents of the same class.

Ce que signifie cette interaction, en termes simples

Carmustine and Lomustine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Carmustine belongs to Oncology; Lomustine belongs to Oncology.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive alkylating cytotoxicity affecting bone marrow and lung tissue.

Conduite à tenir

Avoid concurrent use where possible. If sequential use is needed, monitor blood counts weekly for several weeks and check pulmonary function.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Carmustine with Lomustine?

MediHelp rates the interaction as major. Carmustine and Lomustine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are nitrosoureas with delayed, cumulative myelosuppression and pulmonary toxicity. Using them together increases the risk of profound and prolonged cytopenias and lung injury. There is no therapeutic rationale for combining agents of the same class.

How serious is the interaction between Carmustine and Lomustine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible. If sequential use is needed, monitor blood counts weekly for several weeks and check pulmonary function.

What other medicines interact with Lomustine?

MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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