Interactions médicamenteuses
Cefazolin + Streptomycin
Gravité: Modérée
Cefazolin and Streptomycin: moderate interaction.
Dernière mise à jour
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Résumé
Combining cefazolin with streptomycin may increase the chance of renal injury, particularly in patients with reduced kidney function or dehydration. Streptomycin itself carries vestibular and cochlear toxicity, so any added renal impairment can raise drug exposure and worsen ototoxicity.
Ce que signifie cette interaction, en termes simples
Cefazolin and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefazolin belongs to Anti Bacterial; Streptomycin belongs to Anti Bacterial.
Pourquoi elle survient
Additive nephrotoxic potential; reduced renal clearance of streptomycin can increase its toxicity.
Conduite à tenir
Monitor renal function and streptomycin levels, and assess hearing and balance during therapy. Adjust the streptomycin dose for renal function.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Cefazolin
- Amikacin + Cefazolin Modérée
- Bcg vaccine live + Cefazolin Modérée
- Cefazolin + Cholera vaccine Modérée
- Cefazolin + Dexamethasone-tobramycin Modérée
- Cefazolin + Gentamicin Modérée
- Cefazolin + Kanamycin Modérée
Autres interactions de Streptomycin
- Abobotulinumtoxina + Streptomycin Majeure
- Adefovir + Streptomycin Majeure
- Amikacin + Streptomycin Majeure
- Amphotericin b deoxycholate + Streptomycin Majeure
- Amphotericin b + Streptomycin Majeure
- Atracurium + Streptomycin Majeure
Questions fréquentes
Can I take Cefazolin with Streptomycin?
MediHelp rates the interaction as moderate. Cefazolin and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining cefazolin with streptomycin may increase the chance of renal injury, particularly in patients with reduced kidney function or dehydration. Streptomycin itself carries vestibular and cochlear toxicity, so any added renal impairment can raise drug exposure and worsen ototoxicity.
How serious is the interaction between Cefazolin and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and streptomycin levels, and assess hearing and balance during therapy. Adjust the streptomycin dose for renal function.
What other medicines interact with Cefazolin?
MediHelp also lists interactions of Cefazolin with, for example, Amikacin, Bcg vaccine live, Cholera vaccine. The full list is on the Cefazolin page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
