Interactions médicamenteuses
Cefepime + Streptomycin
Gravité: Modérée
Cefepime and Streptomycin: moderate interaction.
Dernière mise à jour
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Résumé
Aminoglycosides are nephrotoxic and ototoxic, and combining them with a cephalosporin has been associated with additional kidney injury in some reports. Cefepime itself carries little direct nephrotoxicity, so the added risk is modest and mainly relevant in patients with existing renal impairment or prolonged therapy.
Ce que signifie cette interaction, en termes simples
Cefepime and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefepime belongs to Anti Bacterial; Streptomycin belongs to Anti Bacterial.
Pourquoi elle survient
Additive renal tubular stress; the aminoglycoside accumulates in proximal tubular and inner ear cells and any reduction in renal function raises its exposure.
Conduite à tenir
Monitor serum creatinine and streptomycin concentrations, and adjust the dose to renal function. Watch for hearing or vestibular symptoms and limit the duration of combined therapy.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Cefepime
- Amikacin + Cefepime Modérée
- Cefepime + Cholera vaccine Modérée
- Cefepime + Dexamethasone-tobramycin Modérée
- Cefepime + Gentamicin Modérée
- Cefepime + Kanamycin Modérée
- Cefepime + Microbiota Modérée
Autres interactions de Streptomycin
- Abobotulinumtoxina + Streptomycin Majeure
- Adefovir + Streptomycin Majeure
- Amikacin + Streptomycin Majeure
- Amphotericin b deoxycholate + Streptomycin Majeure
- Amphotericin b + Streptomycin Majeure
- Atracurium + Streptomycin Majeure
Questions fréquentes
Can I take Cefepime with Streptomycin?
MediHelp rates the interaction as moderate. Cefepime and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides are nephrotoxic and ototoxic, and combining them with a cephalosporin has been associated with additional kidney injury in some reports. Cefepime itself carries little direct nephrotoxicity, so the added risk is modest and mainly relevant in patients with existing renal impairment or prolonged therapy.
How serious is the interaction between Cefepime and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and streptomycin concentrations, and adjust the dose to renal function. Watch for hearing or vestibular symptoms and limit the duration of combined therapy.
What other medicines interact with Cefepime?
MediHelp also lists interactions of Cefepime with, for example, Amikacin, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Cefepime page.
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