Interactions médicamenteuses
Cefixime + Warfarin
Gravité: Modérée
Cefixime and Warfarin: moderate interaction.
Dernière mise à jour
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Résumé
Cephalosporins can increase the anticoagulant effect of warfarin and raise INR in some patients, increasing the risk of bleeding. Infection itself, reduced food intake and antibiotic effects on gut flora also contribute to this change.
Ce que signifie cette interaction, en termes simples
Cefixime and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefixime belongs to Anti Bacterial; Warfarin belongs to Cardiovascular.
Pourquoi elle survient
Probably reduced vitamin K availability from gut flora suppression, with the contribution of the acute illness; direct effect on warfarin metabolism is not established.
Conduite à tenir
Check INR within a few days of starting cefixime and again during and after the course. Reduce the warfarin dose if INR rises and watch for bleeding.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Cefixime
- Cefixime + Typhoid vaccine live Majeure
- Cefixime + Cholera vaccine Modérée
- Cefixime + Kanamycin Modérée
- Cefixime + Microbiota Modérée
- Cefixime + Plazomicin Modérée
- Cefixime + Sodium picosulfate / magnesium oxide / anhydrous citric acid Modérée
Autres interactions de Warfarin
- Defibrotide + Warfarin Contre-indiquée
- Ketorolac + Warfarin Contre-indiquée
- Abciximab + Warfarin Majeure
- Acetylsalicylic acid + Warfarin Majeure
- Adagrasib + Warfarin Majeure
- Amiodarone + Warfarin Majeure
Questions fréquentes
Can I take Cefixime with Warfarin?
MediHelp rates the interaction as moderate. Cefixime and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cephalosporins can increase the anticoagulant effect of warfarin and raise INR in some patients, increasing the risk of bleeding. Infection itself, reduced food intake and antibiotic effects on gut flora also contribute to this change.
How serious is the interaction between Cefixime and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR within a few days of starting cefixime and again during and after the course. Reduce the warfarin dose if INR rises and watch for bleeding.
What other medicines interact with Cefixime?
MediHelp also lists interactions of Cefixime with, for example, Typhoid vaccine live, Cholera vaccine, Kanamycin. The full list is on the Cefixime page.
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